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The spatial organization of cholinergic mosaics in the adult mouse retina
Author(s) -
GalliResta Lucia,
Novelli Elena,
Volpini Maila,
Strettoi Enrica
Publication year - 2000
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.2000.00280.x
Subject(s) - retina , spatial organization , amacrine cell , cholinergic , voronoi diagram , retinal , ganglion cell layer , neuroscience , biology , retinal ganglion cell , spatial analysis , tessellation (computer graphics) , inner plexiform layer , anatomy , computer science , geography , mathematics , evolutionary biology , biochemistry , geometry , remote sensing , computer graphics (images)
We analysed the spatial organization of the cholinergic amacrine cell mosaics in the mouse retina, as part of a general study of the major mouse retinal arrays, aiming at providing intrinsic cellular reference grids to monitor anomalies in retinal growth and/or functional organization in mouse models of retinal degeneration. The spatial organization of the cells was analysed by means of the nearest neighbour distance analysis, as well as by the analysis of Voronoi and Delaunay tesselations. We found non random cell spacing in both cholinergic arrays, although the mosaic in the ganglion cell layer tiles the retina scarcely better than a random distribution. Autocorrelation analysis revealed no detectable pattern in cell positioning, but there was a tendency towards a minimal spacing between array elements. Finally, we found no correlation in the spatial organization of the two arrays.