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Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region
Author(s) -
Good Mark,
Day Mark,
Muir Janice L.
Publication year - 1999
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.1999.00920.x
Subject(s) - long term potentiation , hippocampal formation , hippocampus , nmda receptor , endogeny , ltp induction , synaptic plasticity , neuroscience , neurotransmission , estrous cycle , long term depression , biology , endocrinology , medicine , receptor , ampa receptor
The present study investigated the effects of naturally fluctuating endogenous levels of oestrogen on the induction and maintenance of long‐term potentiation (LTP) and long‐term depression (LTD) in the CA1 region of the hippocampus. Using an anaesthetized in vivo preparation, the results showed that the induction of LTP was augmented during the pro‐oestrous stage of the oestrous cycle. In contrast to LTP, however, the induction of paired‐pulse LTD was severely attenuated during pro‐oestrous, but was clearly manifested by rats during met/dioestrous and oestrous stages of the cycle. These findings are discussed with reference to: (i) the modulatory effects of oestrogen on N‐methyl‐ d ‐aspartate (NMDA) receptor function and γ‐aminobutyric acid (GABA) neurotransmission in the hippocampus; and (ii) the functional implications that such cyclical changes in synaptic plasticity have for learning and memory processes supported by the hippocampus.

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