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Functional NMDA and GABA A receptors in pioneer neurons of the cortical marginal zone
Author(s) -
Soria José Miguel,
MartínezGalán Juan Ramón,
Luján Rafael,
Valdeolmillos Miguel,
Fairén Alfonso
Publication year - 1999
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.1999.00780.x
Subject(s) - glutamate receptor , metabotropic glutamate receptor , gabaa receptor , neuroscience , ionotropic effect , long term depression , metabotropic receptor , nmda receptor , muscimol , receptor , class c gpcr , metabotropic glutamate receptor 5 , metabotropic glutamate receptor 1 , chemistry , biology , ampa receptor , biochemistry
Abstract Transient pioneer neurons in the neocortical marginal zone generate an early corticofugal axonal projection at E12–E16 (Meyer et al . 1998). We have analysed the functional activity of glutamate and GABA receptors in such cells by measuring changes in intracellular calcium concentrations ([Ca 2+ ] i ). The activation of GABA A receptors with muscimol, as well as bath application of glutamate, lead to increases in [Ca 2+ ] i in pioneer neurons. The stimulatory action of glutamate is mostly produced through the NMDA‐type of ionotropic receptors. Metabotropic glutamate receptor activation has no effect on [Ca 2+ ] i . Consistent with such results, immunocytochemical studies showed a prominent expression of GABA A and NMDA receptors in pioneer neurons. The activation of such receptors may be implicated in the remodelling of pioneer neurons during development.