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Overexpression of GAP‐43 induces prolonged sprouting and causes death of adult motoneurons
Author(s) -
Harding D. I.,
Greensmith L.,
Mason M.,
Anderson P. N.,
Vrbová G.
Publication year - 1999
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.1999.00640.x
Subject(s) - sprouting , axotomy , genetically modified mouse , neuroscience , transgene , sciatic nerve , biology , apoptosis , programmed cell death , anatomy , central nervous system , gene , biochemistry , botany
In neurodegenerative diseases, neurons undergo prolonged periods of sprouting. Whether this sprouting compromises these neurons is unknown. Here, we examined the effect of axotomy on adult motoneurons undergoing prolonged sprouting in transgenic mice that overexpress GAP‐43 (growth‐associated protein). Sciatic nerve injury in these adult mice results in motoneuron death, but has no effect in non‐transgenic mice. Thus, continued growth of motor axons renders adult motoneurons susceptible to nerve injury and compromises their long‐term survival. The progressive nature of neurodegenerative diseases may therefore be caused by prolonged sprouting.