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Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury
Author(s) -
Teng Yang Dong,
Mocchetti Italo,
Wrathall Jean R.
Publication year - 1998
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.1998.00100.x
Subject(s) - spinal cord , spinal cord injury , choline acetyltransferase , fibroblast growth factor , basic fibroblast growth factor , neuroscience , neurotrophic factors , in vivo , motor neuron , medicine , nerve growth factor , biology , central nervous system , growth factor , receptor , microbiology and biotechnology
We studied the effect of a single focal injection of recombinant basic (FGF2) or acidic (FGF1) fibroblast growth factor on the survival of spinal motor neurones at 24 h after a standardized spinal cord contusion injury (SCI) in the rat. Both FGF2 and FGF1 (3 μg), microinjected into the injury site at 5 min post‐injury (p.i.), protected at least two functionally important classes of spinal motor neurones, autonomic preganglionic neurones in the intermediolateral (IML) column and somatic motor neurones in the ventral horn (VH). Moreover, there was enhanced choline acetyltransferase (ChAT) immunoreactivity in surviving VH and IML neurones, suggesting an improved functional status. Thus, neurotrophic factors such as FGF2 and FGF1 may contribute to an overall strategy to treat acute SCI and improve recovery of function.