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The intermediate stage and paradoxical sleep in the rat: influence of three generations of hypnotics
Author(s) -
Gottesmann C.,
Gandolfo G.,
Arnaud C.,
Gauthier P.
Publication year - 1998
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1046/j.1460-9568.1998.00069.x
Subject(s) - midazolam , sleep (system call) , non rapid eye movement sleep , zolpidem , psychology , triazolam , paradoxical reaction , brainstem , hypnotic , neuroscience , anesthesia , benzodiazepine , electroencephalography , medicine , psychiatry , insomnia , sedation , tuberculosis , receptor , pathology , computer science , operating system
Paradoxical sleep in the rat, cat and mouse is preceded and sometimes followed by a short‐lasting intermediate stage characterized by high‐amplitude anterior cortex spindles and low‐frequency hippocampal theta rhythm. Several neurophysiological arguments suggest that the intermediate stage corresponds to a brief functional disconnection of the forebrain from the brainstem. This paper is devoted to the review of quantitative and qualitative influences of three generations of hypnotics on the intermediate stage–paradoxical sleep couple. Barbiturates, first‐generation hypnotics, extend the intermediate stage at the expense of paradoxical sleep. Three benzodiazepines are compared, two with a short half‐life (triazolam and midazolam) and one with a long half‐life (diazepam). They also decrease sleep occurrence latency and increase the intermediate stage at the expense of paradoxical sleep, except for midazolam, which increases both the intermediate stage and paradoxical sleep at low dose. Zolpidem and zopiclone, hypnotics of third generation, decrease paradoxical sleep but the intermediate stage never substitutes for paradoxical sleep. The results are discussed in relationship to the functional aspects of this turning‐point period of sleep.