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Is there another chapter in the Helicobacter pylori /peptic ulcer disease story?
Author(s) -
Clancy R. L.,
Pang G.
Publication year - 2001
Publication title -
internal medicine journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.596
H-Index - 70
eISSN - 1445-5994
pISSN - 1444-0903
DOI - 10.1046/j.1445-5994.2001.00034.x
Subject(s) - helicobacter pylori , medicine , disease , peptic ulcer , epidemiology , peptic , spirillaceae , antibiotics , intensive care medicine , immunology , gastroenterology , gastritis , microbiology and biotechnology , biology
The role of Helicobacter pylori in the production of mucosal damage has largely been considered within a simple infection paradigm, because to date eradication has appeared to be a predictable outcome of antibiotic therapy. Changes in the epidemiology and management of peptic ulcer disease, however, require a more comprehensive framework to understand these shifting clinical patterns. The present review examines mucosal damage as an outcome of a complicated host–parasite relationship, with alterations in both parasite physiology and host defence mechanisms being keys to understanding disease patterns. (Intern Med J 2001; 31: 181–183)