Open AccessStudies on the effects of initial injection doses of follicle stimulating hormone on the pregnancy and the ovarian hyperstimulation syndrome incidence in polycystic ovarian syndrome patients
Author(s) -
Nakamura Yasuhiko,
Takasaki Akihisa,
Sugino Norihiro,
Tamura Hiroshi,
Takiguchi Shuji,
Takayama Hisako,
Harada Ayako,
Kato Hiroshi
Publication year - 2003
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1046/j.1445-5781.2003.00022.x
Subject(s) - ovarian hyperstimulation syndrome , medicine , ovulation , pregnancy rate , pregnancy , follicle stimulating hormone , polycystic ovary , ovulation induction , gonadotropin , gynecology , endocrinology , hormone , luteinizing hormone , in vitro fertilisation , biology , insulin resistance , insulin , genetics
Background: Patients with polycystic ovarian syndrome (PCOS) are often resistant to clomiphene citrate, which causes the need for subsequent gonadotropin treatment. However, careful administration is required because of the potential side‐effects, that is, ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy. Methods: Forty‐three cycles in 22 patients with PCOS were enrolled in this study. Ovarian stimulation was initiated on day 7 of the menstrual cycle with 150 IU/day of follicle stimulating hormone (FSH; 150 IU course), 100 IU/day (100 IU course), and 75 IU/day (75 IU course), successively. If follicles over 12 mm in diameter did not develop after 1 week, the dose was increased. In each treatment course, the number of developed follicles, the serum estradiol level before ovulation, total FSH dosage and duration of administration, the incidence of OHSS, and pregnancy rate were examined. Results and Conclusion: The largest number of developed follicles and the highest serum estradiol level were found in the 150 IU course. In contrast, the total FSH dosage and duration of administration were highest and longest in the 75 IU course. The incidence of OHSS and pregnancy rate were highest in the 150 IU course and in the 75 IU course, respectively. The present study indicates that 100 IU or 75 IU of FSH is recommended as an initial injection dose for PCOS patients. (Reprod Med Biol 2003; 2 : 63–67)