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Intestinal adaptation in short bowel syndrome
Author(s) -
Welters Carlo F. M.,
Dejong Cornelius H. C.,
Deutz Nicolaas E. P.,
Heineman Erik
Publication year - 2002
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1046/j.1445-2197.2002.02357.x
Subject(s) - short bowel syndrome , crypt , adaptation (eye) , medicine , enteral administration , intestinal resection , function (biology) , barrier function , intestinal mucosa , gastroenterology , parenteral nutrition , resection , microbiology and biotechnology , biology , surgery , neuroscience
Regaining enteral autonomy after extensive small bowel resection is dependent on intestinal adaptation. This adaptational process is characterized by hyperplastic growth of the remaining gut, which is accompanied by both an increase of cell division at the level of the crypt cells and by an increased rate of programmed cell death (apoptosis). Apart from the absorptive function, the small bowel also has a barrier function and plays an important role in interorgan metabolism. Also, these functions are greatly affected by a massive intestinal resection and subsequent recovery by intestinal adaptation. This review aims to give an overview of the debilitating effects of massive intestinal resection on gut function and subsequently discusses intestinal adaptation and possible factors stimulating adaptation.