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Glutathione
Author(s) -
Jefferies Heather,
Coster Jane,
Khalil Alizan,
Bot Joan,
McCauley Rosalie D.,
Hall John C.
Publication year - 2003
Publication title -
anz journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 70
eISSN - 1445-2197
pISSN - 1445-1433
DOI - 10.1046/j.1445-1433.2003.02682.x
Subject(s) - glutathione , tripeptide , reactive oxygen species , redox , biochemistry , cell , metabolism , medicine , microbiology and biotechnology , biology , enzyme , chemistry , amino acid , organic chemistry
Glutathione (GSH) is an ubiquitous thiol‐containing tripeptide that plays a key role in cell biology. It modulates cell response to redox changes associated with the reactive oxygen species, detoxifies the metabolites of drugs; regulates gene expression and apoptosis, and is involved in the transmembrane transport of organic solutes. Polymorphism has been observed in key enzymes of GSH metabolism and some alleles have been associated with an impaired redox buffer system downsteam diseases, and susceptibility to ischaemia. These varied activities make GSH an attractive target for a more reductionist approach to the prevention and management of many conditions of interest to surgeons.