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Multiple ileal ulcers and an ileal Dieulafoy's lesion induced by loxoprofen sodium
Author(s) -
SUZUKI GAKU,
OOISHI MASAE,
KATO TAKASHI,
KUNIEDA YASUYUKI,
ISHIZAKI TADAHUMI,
NAKAYAMA MASATO,
NAKAJIMA NOBUHISA,
YONEYAMA SHIGETO,
TAKAGI TOMOTAKA,
KATO MOTOTSUGU,
ASAKA MASAHIRO
Publication year - 2003
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1046/j.1443-1661.2003.00255.x
Subject(s) - medicine , lesion , wedge resection , enteroscopy , gastroenterology , sodium , surgery , endoscopy , resection , chemistry , organic chemistry
Loxoprofen sodium is one of the non‐steroidal anti‐inflammatory drugs (NSAIDs) that is a prodrug. Several adverse effects of the drug have been described, but ileal ulcer has not been reported so far. We experienced an 87‐year‐old male patient with disk herniation complicated with loxoprofen sodium‐induced multiple ileal ulcers and an ileal Dieulafoy's lesion that caused massive intestinal bleeding. The patient was saved by wedge resection of the Dieulafoy's lesion and discontinuance of the NSAID. 99m Tc‐red blood cell scintigraphy and intraoperative enteroscopy of the small bowel were useful in the diagnosis. This is the first case of multiple ileal ulcers with an ileal Dieulafoy's lesion induced by loxoprofen sodium.