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Helicobacter Pylori and Precancerous Gastric Lesions
Author(s) -
Cu Pham Quang,
Huyen Nguyen Xuan,
Luan Trinh Thi,
Hung Nguyen Quang,
Hop Tran Van
Publication year - 2000
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1046/j.1443-1661.2000.0048a.x
Subject(s) - helicobacter pylori , intestinal metaplasia , medicine , gastroenterology , atrophic gastritis , giemsa stain , dysplasia , gastritis , rapid urease test , biopsy , serology , pathology , antibody , immunology
Background: To determine the relationship between Helicobacter pylori ( H. pylori ) infection and the precancerous gastric lesions: atrophic gastritis (AG) and intestinal metaplasia (IM) and dysplasia. Methods: A total of 347 dyspeptic patients, including 141 H. pylori ‐positive patients and 206 H. pylori ‐negative patients, were studied alongside age‐ and sex‐matched controls. The patients underwent gastroscopy and endoscopic biopsy for detection of H. pylori , and histological examinations. Helicobacter pylori was detected by a urease test (CLO; Delta West; Bentley, Australia), by histology (H&E stain, Giemsa) and by serology (BioSig; BioMeditech, NJ, USA). Atrophic gastritis, IM and dysplasia were detected by histological examination (Giemsa, H&E stain). Results: There is a higher rate of atrophic gastritis in H. pylori ‐positive than in H. pylori ‐negative patients (46 vs 13.5%, odds ratio (OR) = 5.4; P < 0.01). Gastritis in H. pylori ‐positive patients also has a higher rate of activity than in H. pylori ‐negative patients. The rate of IM is higher in H. pylori ‐positive patients than in H. pylori ‐negative patients (35 vs 11%; OR = 4.3; P < 0.01). Metaplasia is more often diffuse in H. pylori ‐positive than in H. pylori ‐negative patients. Dysplasia is more common in H. pylori ‐positive than in H. pylori ‐negative patients (12 and 3.8%; OR = 3.3; P < 0.01). Conclusions: This study supports the suggestion of a relationship between H. pylori infection and precancerous gastric lesions. Wherever H. pylori is present, the precancerous lesions are more common and more severe.