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Lack of effect of gender on retinopathy in the mouse
Author(s) -
Higgins Rosemary D,
Yan Yun,
Tadesse Misrak,
Yossuck Panitan
Publication year - 2001
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1046/j.1442-9071.2001.00441.x
Subject(s) - retinopathy of prematurity , retinopathy , medicine , quartile , retinal , ophthalmology , blood vessel , retina , physiology , endocrinology , gestational age , biology , pregnancy , confidence interval , genetics , neuroscience , diabetes mellitus
Background : The reported effect of gender on retinopathy of prematurity has been controversial. The goal of this study was to determine the effect of gender on oxygen‐induced retinopathy in a mouse model. Methods : Oxygen‐induced retinopathy was produced in C57BL6 mice by exposure to 75% oxygen from postnatal day (P) 7 for 5 days. Animals were returned to room air on P12 and killed on P17–21. Gender was determined by inspection. Retinopathy was evaluated by a retinopathy scoring system and by quantification of extraretinal neovascular nuclei on retinal sections. Results : Both males and females developed similar degrees of retinopathy. Males had a median total retinopathy score of 9 (25th, 75th quartile: 8, 11) and females had score of 9 (25th, 75th quartile: 7,10). Retinal subscores of blood vessel growth, blood vessel tufts, extraretinal neovascularization, haemorrhage and blood vessel tortuosity were similar in both groups. Males and females had a similar number of neovascular nuclei on retinal sections. Conclusions : Gender does not alter the development of oxygen‐induced retinopathy in the C57BL6 mouse.

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