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The contribution of cone responses to rat electroretinograms
Author(s) -
Nixon Peter J,
Bui Bang V,
Armitage James A,
Vingrys Algis J
Publication year - 2001
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1046/j.1442-9071.2001.00402.x
Subject(s) - scotopic vision , erg , electroretinography , cone (formal languages) , medicine , photopic vision , optics , retina , physics , ophthalmology , mathematics , algorithm
The contribution of rods and cones to the scotopic electroretinogram (ERG) of small animals is unclear, with a recent report suggesting that the mouse has no cone a‐wave. The present study considered the contribution of cones to the ERG of the rat. Dark‐adapted Long Evans rats ( n = 4) had ERG signals collected following a single flash, which stimulated rods and cones (mixed response), or a twin‐flash paradigm (short interstimulus interval, 1 s), which isolated cone responses. Rod signals were derived by digital subtraction of the cone signal from the mixed rod/cone ERG. The rat a‐wave was found to be dominated by rod responses but cone responses contributed substantially (45%) to post‐receptoral waveforms (b‐wave) at higher light levels.