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Effects of a non‐steroidal (ketorolac tromethamine) and a steroidal (dexamethasone) anti‐inflammatory drug on refractive state and ocular growth
Author(s) -
Luu Chi D,
Foo Hayley,
Crewther Sheila G,
Crewther David P
Publication year - 2001
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1046/j.1442-9071.2001.00400.x
Subject(s) - ketorolac , ketorolac tromethamine , dexamethasone , medicine , saline , vitreous chamber , ophthalmology , pharmacology , refractive error , anesthesia , endocrinology , analgesic , eye disease
Topical steroidal anti‐inflammatory drugs (SAID) and non‐steroidal anti‐inflammatory drugs (NSAID) are known to affect fluid balance. The effects of twice daily topical applications of Maxidex (dexamethasone, a SAID), Acular (ketorolac, a NSAID), and saline were examined biometrically on the development of refractive errors and eye growth in chicks raised from days 3–12 wearing either a monocular +10 D, 0 D, or –10 D lens. Biometric analysis showed that neither SAID nor NSAID nor saline affected refractive error compensation but that the anti‐inflammatory drugs affected eye growth. In chicks reared with a +10 D lens, dexamethasone induced a decrease in axial length (AL), vitreous chamber (VC) and anterior chamber (AC) depth, while ketorolac only induced a decrease in AC. In –10 D lens chicks dexamethasone again induced a decrease in AL and VC, but did not affect AC depth, whereas ketorolac only induced an increase in AC depth. Taken together, these results suggest that anti‐inflammatory drugs can induce changes in ocular size without affecting refractive state and, as such, have implications for the management of progressive myopia.