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Aggressive angiomyxoma in the scrotum expressing androgen and progesterone receptors
Author(s) -
CHIHARA YOSHITOMO,
FUJIMOTO KIYOHIDE,
TAKADA SATOSHI,
HIRAYAMA AKIHIDE,
CHO MASAKI,
YOSHIDA KATSUNORI,
OZONO SEIICHIRO,
HIRAO YOSHIHIKO
Publication year - 2003
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2003.00716.x
Subject(s) - aggressive angiomyxoma , androgen receptor , medicine , estrogen receptor , scrotum , immunostaining , perineum , pathology , progesterone receptor , androgen , estrogen , receptor , immunohistochemistry , soft tissue , anatomy , cancer , prostate cancer , hormone , breast cancer
Aggressive angiomyxoma is a rare benign mesenchymal myxoid tumor that arises from the pelvic soft tissues and perineum in relatively young females. This tumor has the ability to infiltrate locally and has a high risk of local recurrence after extirpation, but no potential to metastasize. We report here a rare case of aggressive angiomyxoma that developed in the scrotum of a 47‐year‐old male. Immunostaining of the resected specimen revealed that the tumor cell nuclei stained strongly and diffusely for androgen receptors (80% of the tumor cells), and moderately and partly for progesterone receptors (20% of the tumor cells). However, staining was negative for estrogen receptors. It is highly suggested that the growth of aggressive angiomyxoma in males may depend on androgen manipulation, contrary to its frequent and close association with estrogen receptor expression, which has been reported in females.