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Successful long‐term disease‐free survival following multimodal treatments in a patient with a repeatedly recurrent refractory adrenal cortical carcinoma
Author(s) -
FUJII YASUHISA,
KAGEYAMA YUKIO,
KAWAKAMI SATORU,
MASUDA HITOSHI,
ARISAWA CHIZURU,
AKAMATSU HIDEKI,
AKASHI TAKUMI,
KIHARA KAZUNORI
Publication year - 2003
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2003.00651.x
Subject(s) - medicine , etoposide , surgery , refractory (planetary science) , carboplatin , multimodal therapy , chemotherapy , metastasis , adrenocortical carcinoma , cisplatin , carcinoma , transplantation , cancer , physics , astrobiology
A 47‐year‐old male patient underwent surgery for a 10‐cm adrenal cortical carcinoma. A large invasive adrenal mass was surgically removed en bloc with the right kidney and the lower lobe of the liver. Two months postoperatively, a 7‐cm recurrent mass developed in the right psoas muscle. After a partial response was achieved by irradiation (40 Gy) and high‐dose chemotherapy (carboplatin and etoposide) with peripheral blood stem cell transplantation, the patient underwent surgery with a wide excision of the psoas muscle. Twelve months after the initial surgery, an 8‐cm rib metastasis developed and the patient again underwent surgery after a combination of irradiation (50 Gy) and chemotherapy (cisplatin and etoposide). The patient has been doing well without any evidence of recurrence for 5 years. Refractory or metastatic adrenal cortical carcinomas have been thought to be lethal, therefore, the present case provides support for multimodal treatments of refractory adrenocortical cancers.