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Advanced renal cell carcinoma treated with granulocyte‐macrophage colony‐stimulating factor gene therapy: A clinical course of the first Japanese experience
Author(s) -
Kawai Koji,
Tani Kenzaburo,
Yamashita Naohide,
Tomikawa Shinji,
Eriguchi Masazumi,
Fujime Makoto,
Okumura Ko,
Kakizoe Tadao,
Clift Shirley,
Ando Dale,
Mulligan Richard,
Yamauchi Atsusi,
Noguchi Masayuki,
Asano Shigetaka,
Akaza Hideyuki
Publication year - 2002
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2002.00493.x
Subject(s) - medicine , renal cell carcinoma , genetic enhancement , granulocyte macrophage colony stimulating factor , immunotherapy , pathology , cancer , oncology , immunology , cytokine , gene , biochemistry , chemistry
A phase I study of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) gene‐transduced tumor vaccine for patients with metastatic renal cell carcinoma (RCC) was initiated in 1998, as the first cancer gene therapy in Japan. The study is still ongoing, but the first patient is presented here as a case report. The patient was a 60‐year‐old man with Stage IV CRC with multiple lung metastases. After surgical resection of the tumor, autologous tumor cells were transduced and cultured to produce GM‐CSF. The patient received a total of 2.2 × 10 8 gene‐transduced autologous vaccine cells by subcutaneous injection. During the course of vaccination, growth of the largest metastatic mass slowed to some extent; however, multiple new lesions developed. About 1 month after the start of low‐dose IL‐2 therapy, rapid and remarkable regression in a large lung hilar metastatic mass was noticed. The patient died of progressive disease 7 months after the start of GM‐CSFgene therapy. Careful histological examination by autopsy revealed that the responding mass was infiltrated by CD8 positive dominant T lymphocytes, and did not exhibit vasculitis or any other changes associated with active autoimmune disease.