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Urinary transforming growth factor‐β1 levels correlate with bladder outlet obstruction
Author(s) -
Monga Manoj,
GabalShehab Lamia L,
Stein Paul
Publication year - 2001
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2001.00356.x
Subject(s) - medicine , urology , urinary system , bladder outlet obstruction , transforming growth factor , urinary bladder , urinary obstruction , prostate , cancer
Background: Urinary transforming growth factor‐β1 (TGF‐β1) levels have been shown to correlate with elevated intrapelvic pressure associated with ureteropelvic junction obstruction. Other studies have evaluated urinary TGF‐β1 levels in prostate cancer. This study tests the hypothesis that urinary TGF‐β1 levels might correlate with objective measures of bladder outlet obstruction (BOO). Methods: Twenty‐three men (age: 46–85 years) with lower urinary tract symptoms underwent urodynamic studies consisting of non‐invasive uroflowmetry, cystometrogram and voiding pressure flow studies. Patients were classified as obstructed ( n = 17) or not obstructed ( n = 6) based on Abrams‐Griffith nomograms. Urinary TGF‐β1 was extracted from an aliquot of urine obtained at the time of bladder catheterization for urodynamic studies. Urinary TGF‐β1 levels were then determined by enzyme‐linked immunosorbent assay (ELISA). Results: There was a strong correlation between urinary TGF‐β1 levels and the presence of obstruction by Abrams‐Griffith nomogram criteria ( P = 0.025). Urinary TGF‐β1 levels were significantly higher in men with obstruction (0.039 ± 0.011 pg/mL) than in men without obstruction (0.029 ± 0.009 pg/mL; P = 0.036). Conclusion: Urinary TGF‐β1 levels correlate with objective measures of BOO. Further study is needed to test the utility of urinary TGF‐β1 as a non‐invasive diagnostic tool for BOO.