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Gene and immune therapy for renal cell carcinoma
Author(s) -
Pantuck Allan J,
Zisman Am,
Belldegrun Arie
Publication year - 2001
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2001.00326.x
Subject(s) - medicine , immunotherapy , renal cell carcinoma , immune system , genetic enhancement , kidney cancer , carcinoma , cancer research , gene , oncology , immunology , biology , biochemistry
Conventional therapy for metastatic renal cell carcinoma is associated with a poor response rate and few patients are long‐term survivors. The occurrence of spontaneous regression and the prolonged latency period between primary tumor removal and the appearance of metastases in some patients suggest the existence of important host immune responses to autologous tumor cells. With the advent of molecular gene transfer techniques and increased knowledge of the basic pathways of immune activation, the field of cancer immunotherapy has finally begun to develop novel and effective approaches for harnessing the immune system as a therapeutic agent. Current immunotherapy and gene therapy strategies, including methods of cytokine delivery and tumor‐cell‐based vaccines, are presented.