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Effect of ethyl icosapentate on urinary calcium and oxalate excretion
Author(s) -
Konya Eiji,
Tsuji Hidenori,
Umekawa Tohru,
Kurita Takashi,
Iguchi Masanori
Publication year - 2000
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2000.00211.x
Subject(s) - hypercalciuria , urinary calcium , medicine , calcium , urinary system , uric acid , urine , excretion , calcium oxalate , oxalic acid , creatinine , endocrinology , chemistry , biochemistry
Background: The effect of ethyl icosapentate (EPA‐E) on urinary calcium and oxalic acid excretion was examined to evaluate whether EPA‐E is useful in the prevention of calcium‐containing urinary stones. Methods: For 6 months, urine was measured daily from 40 calcium‐containing urinary stone producers at an outpatient clinic, before and after the administration of 1800 mg/day EPA‐E. The urine was measured for volume, urea nitrogen, creatinine, calcium, magnesium, phosphorus, uric acid, oxalic acid and citric acid. Serum total cholesterol and triglyceride were also measured. Results: Urinary calcium excretion was not reduced in any of the patients or particular hypercalciuric groups, nor did the level of calcium change. However, nine of the 25 hypercalciuric patients experienced a significant urinary calcium reduction to the normal calciuric level (a reduction of approximately 44%). It is not known why these particular patients experienced a reduction. Urinary oxalic acid did not change, whether hypercalciuria was present or not. Conclusions: These findings suggest that EPA‐E is not particularly effective in reducing urinary calcium excretion in the hypercalciuric patients, but it needs future investigation because some patients experienced significant urinary calcium reduction.