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High‐dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer
Author(s) -
Miyazaki Jun,
Miyanaga Naoto,
Kawai Koji,
Shimazui Toru,
Takeshima Hitoshi,
Akaza Hideyuki
Publication year - 2000
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2000.00187.x
Subject(s) - medicine , chemotherapy , etoposide , carboplatin , testicular cancer , cyclophosphamide , surgery , radiation therapy , cancer , transplantation , progressive disease , oncology , cisplatin
AbstractBackground: The present study was performed in order to investigate the efficacy and safety of high‐dose chemotherapy for the treatment of patients with advanced testicular cancer.Methods: Seven patients were treated with high‐dose carboplatin, etoposide and cyclophosphamide followed by peripheral blood stem cell transplantation. Five patients received one cycle and two patients received two cycles of the high‐dose chemotherapy.Results: Of the seven patients, one achieved a complete response and four achieved partial responses with markers negative. As a result of subsequent surgery for residual tumors, three of the four partial responders showed no residual cancer cells. One patient who did not undergo surgery received radiotherapy after the high‐dose chemotherapy and the residual tumors disappeared. All five patients who had either a complete or partial response are still alive and without evidence of disease at 12, 27, 30, 37 and 40 months. One patient is alive with disease at 7 months and one died of progressive disease at 6 months. The hematologic recovery after high‐dose chemotherapy was rapid and non‐hematologic toxicities were usually mild and manageable.Conclusions: High‐dose chemothrapy followed by peripheral blood stem cell transplantation is safe and effective for use in patients with far‐advanced testicular cancer, particularly when the high‐dose chemotherapy is conducted as the initial treatment. Further larger and long‐term follow‐up studies are needed to define the role of high‐dose chemotherapy on testicular cancer.