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Simultaneous production of granulocyte colony‐stimulating factor and parathyroid hormone‐related protein in bladder cancer
Author(s) -
Ueno Munehisa,
Ban ShinIchi,
Ohigashi Takashi,
Nakanoma Takashi,
aka Shoichi,
Hirata Risa,
Iida Masahiro,
Deguchi Nobuhiro
Publication year - 2000
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2000.00141.x
Subject(s) - medicine , leukocytosis , parathyroid hormone related protein , granulocyte colony stimulating factor , bladder cancer , parathyroid hormone , immunohistochemistry , hormone , calcium , cystectomy , cancer , urology , pathology , endocrinology , gastroenterology , chemotherapy
A case of bladder cancer with simultaneous production of granulocyte colony‐stimulating factor (G‐CSF) and parathyroid hormone‐related protein (PTHrP) is reported. An 81‐year‐old male patient was admitted to the Saitama Medical School for treatment of gross hematuria, leukocytosis and hypercalcemia and diagnosed as having advanced bladder cancer. Immediately after a cystectomy was carried out, his white cell count and serum calcium levels returned to normal. However, the tumors recurred locally and the recurrence was accompanied by an increase in the serum G‐CSF and PTHrP levels with a recurrent elevation of white cell count and the serum calcium level. The production of G‐CSF and PTHrP in the tumor cells was confirmed by immunohistochemistry.