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A case of neuroleptic malignant syndrome in a patient with hemodialysis
Author(s) -
Kunishima Yasuharu,
Masumori Naoya,
Kadono Masao,
Tsukamoto Taiji
Publication year - 2000
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.2000.00138.x
Subject(s) - medicine , discontinuation , neuroleptic malignant syndrome , hemodialysis , chronic renal failure , muscle rigidity , pediatrics , intensive care medicine , anesthesia
A 63‐year‐old man with chronic renal failure who had received hemodialysis three times per week for 4 years developed neuroleptic malignant syndrome 10 days after taking amoxapine. His condition was characterized by muscle rigidity, elevation of body temperature and altered consciousness. Although he was treated with dantrolen and supportive care as well as discontinuation of amoxapine, his condition rapidly deteriorated, resulting in death. Because the pharmacokinetics of drugs, especially those such as antidepressants, in patients with chronic renal failure has not been fully clarified, one should be careful about giving such patients these drugs.