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Extragonadal germ cell tumor of the prostate associated with Klinefelter’s syndrome
Author(s) -
NAMIKI KAZUNORI,
TSUCHIYA AKIRA,
NODA KENJIRO,
OYAMA HIRONORI,
ISHIBASHI KEIICHIRO,
KUSAMA HIROSHI,
FURUSATO MASAKUNI
Publication year - 1999
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.1999.06314.x
Subject(s) - medicine , prostate , vinblastine , bleomycin , germ cell , yolk sac , germ cell tumors , chemotherapy , klinefelter syndrome , pathology , urology , oncology , cancer , embryo , biochemistry , chemistry , biology , gene , microbiology and biotechnology
Purpose: We report on a case of extragonadal germ cell tumor of the prostate associated with Klinefelter’s syndrome. Methods/Results: The patient was a 33‐year‐old man. A transrectal prostate biopsy suggested combined germ cell tumor (yolk sac tumor + teratoma). Because there was no tumor except from the prostate, we considered this case to be a primary extragonadal germ cell tumor of the prostate. The prostate tumor responded to systemic chemotherapy with cisplatin, vinblastine and bleomycin and elevated lactate dehydrogenase and α‐fetoprotein levels normalized. In addition to chemotherapy, the patient also underwent radiation therapy. Conclusion: The patient has survived for approximately 4 years since the diagnosis.