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Long‐term (4 year) efficacy and tolerability of doxazosin for the treatment of concurrent benign prostatic hyperplasia and hypertension
Author(s) -
Fawzy Ahmed,
Hendry Angela,
Cook Eileen,
Gonzalez Francisco
Publication year - 1999
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1046/j.1442-2042.1999.00071.x
Subject(s) - doxazosin , medicine , tolerability , urology , hyperplasia , adverse effect , blood pressure , clinical trial
Background: The α 1 ‐adrenoceptor antagonist doxazosin has proved successful in treating patients with concurrent benign prostatic hyperplasia (BPH) and hypertension in short‐term studies. However, both conditions are chronic and may worsen over time. The aim of this study was, therefore, to examine the tolerability and efficacy of doxazosin in the long‐term treatment of concurrent BPH and hypertension. Methods : This study was a longitudinal extension of earlier double‐blind trials. Patients were enrolled into the study on a rolling basis. From a total of 178 BPH patients with hypertension enrolled into the study, 28 had reached 48 months of open‐label treatment with doxazosin at the time of the final data cutoff. Results: Treatment with doxazosin resulted in sustained benefits for BPH patients over the whole study period, with significant improvements in the severity (12.2%, P < 0.001) and bothersomeness (13.2%, P < 0.001) of BPH symptoms, and in the maximum urinary flow rate (26.6%, P < 0.05) from baseline to the end of the 4‐year period. There was also a significant and sustained reduction in diastolic blood pressure. The efficacy of doxazosin treatment for both BPH and hypertension was maintained over the 4‐year period, despite the tendency of these conditions to worsen with time. Comparison of adverse events in patients with long‐ and short‐term hypertension and BPH demonstrates that the safety of doxazosin is not altered during long‐term therapy. Conclusions : This study demonstrates that doxazosin appears to be well tolerated and efficacious in the long‐term management of concurrent BPH and hypertension.