Premium
Human herpesvirus‐6 infection in neonates: Not protected by only humoral immunity
Author(s) -
Sugimoto Tomoko,
TanakaTaya Keiko,
Ono Jiro,
Miyoshi Hiroko,
Okada Shintaro,
Yamanishi Koichi
Publication year - 2002
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2002.01562.x
Subject(s) - human herpesvirus 6 , medicine , virology , antibody , peripheral blood mononuclear cell , immunology , immunity , humoral immunity , immune system , polymerase chain reaction , titer , virus , herpesviridae , viral disease , biology , gene , in vitro , biochemistry
Background: Infants are usually protected from various viral infections, including human herpesvirus‐6 (HHV‐6) and human herpesvirus‐7 (HHV‐7) infections, during the early infantile period by antibodies transferred from their mothers. However, rare cases of exanthem subitum (ES) in neonates have been described in published reports.Methods: From the infantile patients of febrile illness, HHV‐6 and HHV‐7 DNA were examined by the polymerase chain reaction method. Antibodies to HHV‐6 and HHV‐7 were detected by indirect immunofluorescence assay and neutralization test. Viral isolation was attempted from the patient’s peripheral blood mononuclear cells (PBMC) during the acute phase of febrile illness.Results: Human herpesvirus‐6 was verified virologically in two neonates who were clinically diagnosed as ES within the first month of life. Although high copies of HHV‐6 DNA were detected in their PBMC during the acute phase, the isolation of HHV‐6 from their PBMC was not successful. Neutralizing antibodies to HHV‐6 were detected in sera of the acute phase, and those antibodies were considered to be transferred from their mothers. Antibody titers showed fourfold elevation in sera of the convalescent phase. The HHV‐6 infection occurred despite the presence of pre‐existing maternal antibody. Human herpesvirus‐7 and HHV‐7 DNA were not detected from their clinical samples.Conclusions: This observation suggests that HHV‐6 infection could not be protected by only humoral immunity.