Premium
Giant coronary aneurysms due to Kawasaki disease: A case−control study
Author(s) -
Nakamura Yosikazu,
Yashiro Mayumi,
Oki Izumi,
Tanihara Shinichi,
Ojima Toshiyuki,
Yanagawa Hiroshi
Publication year - 2002
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2002.01551.x
Subject(s) - kawasaki disease , medicine , aneurysm , odds ratio , disease , univariate analysis , cardiology , surgery , pediatrics , multivariate analysis , artery
Background: Epidemiologic features of giant coronary aneurysm due to Kawasaki disease and its risk factors are still not clear.Methods: Sixty‐six patients with giant coronary aneurysms were reported to a 15th nationwide survey of Kawasaki disease in Japan. With all other patients treated in the same hospital as a control group, odds ratios were calculated for certain potential risk factors.Results: Infant males aged less than 1 year, neutrophil concentration among leukocyte, late administration of Intravenous gammaglobulin (IVGG) therapy and additional administration of IVGG were considered as risk factors of giant coronary aneurysms due to Kawasaki disease. In univariate analysis, use of IVGG therapy and a large amount of IVGG (2500+ mg/kg) elevated the risk, whereas the relationship disappeared after the adjustment.Conclusions: The observation of 66 cases with giant coronary aneurysms due to Kawasaki disease reported to the nationwide survey provides some risk factors and consideration about the aneurysms.