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Effect of hemodialysis on carnitine levels in children with chronic renal failure
Author(s) -
Mir Sevgi,
Kantar Mehmet,
Yalaz Mehmet,
Keskinoglu Ahmet,
Coker I¸Sil,
Huseyinov Afig
Publication year - 2002
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2002.01498.x
Subject(s) - medicine , hemodialysis , carnitine , chronic renal failure , dialysis , endocrinology , kidney , plasma levels , gastroenterology , urology
Background: Impaired structural and metabolic integrity of the kidney in chronic renal failure (CRF) effects carnitine metabolism by means of many factors. Depletion due to hemodialysis (HD) is one of the major concerns. The aim of the study was to investigate the effects of chronic renal failure and HD on plasma free carnitine (FC) concentrations in children.Methods: Plasma FC concentrations weremeasured in age‐matched 14 undialyzed patients, 20 dialyzed patientsand 12 healthy children. In the HD group, measurements were donepre‐ and postdialysis and an hour after ceasing HD. None of thechildren have been receiving exogenous l ‐carnitine replacement.Results: Plasma FC concentrations on eitherHD or conservative treatment were found to be decreased as comparedto the healthy subjects ( P < 0.001and P = 0.001, respectively).The patients on HD had lower levels of plasma FC at the predialysisperiod than those on conservative treatment ( P = 0.01).The FC levels significantly dropped at the postdialysis period ascompared to those at the predialysis period ( P < 0.001), but recovered at 1 h after ceasing HD. The mean duration of HD did not correlate with plasma FC levels at predialysis period.Conclusions: Children with CRF, either dialyzed or undialyzed, have decreased plasma FC levels. Hemodialysis treatment significantly depletes plasma FC concentrations during the procedure, but predialysis levels are reached 1 hr after ceasing HD.