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Surfactant protein (SP) B associations and interactions with SP‐A in white and black subjects with respiratory distress syndrome
Author(s) -
Floros Joanna,
Fan Ruzong,
Diangelo Susan,
Guo Xiaoxuan,
Wert John,
Luo Junming
Publication year - 2001
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2001.01474.x
Subject(s) - medicine , genotype , respiratory distress , odds ratio , single nucleotide polymorphism , intron , snp , genetics , gene , biology , surgery
Background: The etiology of respiratory distress syndrome (RDS) is multifactorial and/or multigenic. Surfactant protein A (SP‐A) and/or SP‐B genetic variants have been identified as risk or protection factors for RDS.Methods: We genotyped subjects with and without RDS for the SP‐B intron 4 size variants (invariant (inv), deletion (del), insertion (ins) and for four (–18 (A/C), 1013 (A/C), 1580 (C/T), 9306 (A/G)) SP‐B single nucleotide polymorphisms (SNP), to study case–control associations in black and white subjects. We also determined whether specific SP‐B variants interact with RDS susceptibility or protective SP‐A variants to enhance or reduce risk for RDS.Results: Based on odds ratio: (1) the SP‐B intron 4 del variant in white subjects is more of an RDS risk factor for males and for subjects of 28 weeks