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Risk factors for severe respiratory syncytial virus‐associated lower respiratory tract infection in children
Author(s) -
Kaneko Mitsunobu,
Watanabe Jun,
Ueno Etsushi,
Hida Mariko,
Sone Tomofumi
Publication year - 2001
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2001.01438.x
Subject(s) - medicine , odds ratio , respiratory system , bronchiolitis , pediatrics , respiratory tract , pneumovirus , logistic regression , univariate analysis , confidence interval , pneumovirinae , lower respiratory tract infection , respiratory tract infections , respiratory disease , virus , multivariate analysis , paramyxoviridae , viral disease , immunology , lung
Background: Respiratory syncytial virus (RSV) is the most important cause of viral lower respiratory tract infection that can be a life‐threatening disease in infants and children. This study was conducted to look for independent risk factors for severe respiratory syncytial virus‐associated lower respiratory tract infection (RSV‐LRI) that required oxygen supplementation or mechanical ventilation.Methods: Medical records of patients younger than 4 years hospitalized with RSV‐LRI at Shizuoka Red Cross Hospital from July 1, 1995 to June 30, 1999 were reviewed. The patients were compared using univariate and multivariate logistic regression analysis.Results: A total of 157 patients were hospitalized with RSV‐LRI at Shizuoka Red Cross Hospital from the study time period. Of these, 20 patients (12.7%) were diagnosed with severe RSV‐LRI. Subjects younger than 3 months of age had an odds ratio (OR) of 59.9 (95% confidence interval (CI) 14.7_244.0) for the dependent variable of severe RSV‐LRI ( P <0.0001). Subjects with a history of congenital heart disease also had an OR of 99.2 (95% C1 8.5–1160.1) ( P <0.0005).Conclusions: Infants younger than 3 months without any underlying diseases may be at high risk for severe RSV‐LRI. Respiratory syncytial virus prophylaxis is needed not only for high‐risk patients, but for healthy early infants.