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Spontaneous labor increases nitric oxide synthesis during the early neonatal period
Author(s) -
Endo Akihiko,
Izumi Hiroyuki,
Ayusawa Mamoru,
Minato Michiyoshi,
Takahashi Shigeru,
Harada Kensuke
Publication year - 2001
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2001.01424.x
Subject(s) - medicine , nitric oxide , venous blood , endogeny , anesthesia , vein , cord blood , endothelin receptor , endothelin 1 , obstetrics , receptor
Background: This paper aimed to assess the influence of spontaneous labor upon endogenous nitric oxide (NO) and endothelin 1 (ET‐1) during transition to extrauterine life.Methods: The serum levels of NO metabolites (the sum of nitrites and nitrates (NOx)) and the plasma level of ET‐1 were determined in 53 healthy full‐term infants (spontaneous labor group; n =40, cesarean delivery group; n =13). In both groups, blood samples were obtained from a cord vein at birth and from a peripheral vein at 5 days of age.Results: The differences in serum NOx concentrations between the spontaneous labor group and the elective cesarean group were not significant at birth. By the age of 5 days, serum NOx concentrations had risen significantly in the spontaneous labor group to become significantly higher in the elective cesarean group.Conclusion: It is speculated that spontaneous labor might enhance endogenous NO synthesis at 5 days of age.