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Denver developmental screening test II for early identification of the infants who will develop major neurological deficit as a sequalea of hypoxic‐ischemic encephalopathy
Author(s) -
Hallioglu Olgu,
Topaloglu Ali Kemal,
Zenciroglu Aysegul,
Duzovali Oznur,
Yilgor Esat,
Saribas Sezen
Publication year - 2001
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2001.01418.x
Subject(s) - medicine , pediatrics , encephalopathy , neonatal intensive care unit , neurological deficit , hypoxic ischemic encephalopathy , neurological examination , adverse effect , anesthesia , surgery
Background: The primary aim of this study was to find widely available, inexpensive, and non‐invasive parameters for early identification or prediction of the infants with hypoxic‐ischemic encephalopathy (HIE) who will have a severe adverse outcome (classified as death or a major neurological deficit).Methods: Fifty‐seven full‐term or near‐term newborn infants with a diagnosis of HIE were consecutively admitted to the neonatal intensive care unit and studied. Occurrence of seizures during the first 24 h, cranial ultrasonography (US) findings within the first 5 days of life, and Denver developmental screening test II (DDST II) at 6 months of age, were analyzed in relation to mortality and neurological status at 2 years of age.Results: Of the 57 infants, 10 were lost to follow‐up. Twenty of the remaining 47 infants had a severe adverse outcome. Among the predictors of severe adverse outcome, occurrence of seizures was found to have a poor predictive accuracy. Cranial US had 100% sensitivity, however with a rather low specificity (55%). However, DDST II at 6 months of age, yielded a very high predictive accuracy (sensitivity=100%, specificity=95%).Conclusion: We conclude that DDST II at 6 months of age could be used in predicting severe neurological outcome in infants with HIE.