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Effects of albumin infusion therapy on total and unbound bilirubin values in term infants with intensive phototherapy
Author(s) -
Hosono Shigeharu,
Ohno Tsutomu,
Kimoto Hirofumi,
Nagoshi Ren,
Shimizu Masaki,
Nozawa Masayo
Publication year - 2001
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2001.01338.x
Subject(s) - medicine , bilirubin , albumin , serum albumin , gestational age , gastroenterology , human albumin , low birth weight , pregnancy , biology , genetics
Background: The purpose of the present study was to evaluate the effect of intravenous albumin administration on the serum total and unbound bilirubin values in term non‐hemolytic hyperbilirubinemic neonates during intensive phototherapy.Methods: Fifty‐eight infants (gestational age 39.4~1.4 weeks; birth weight 3245~435 g) were given phototherapy with similar light energy. Twenty infants (control group) received only phototherapy, while 38 others (albumin‐treated group) were also given human albumin at 1 g/kg bodyweight, i.v., during the first 2 h of phototherapy.Results: When comparing changes in total and unbound bilirubin values 0, 2, 6 and 24 h after entering the study between the albumin‐treated group and the control group, there was a significant reduction in the serum unbound bilirubin values at the end of albumin treatment and at 6 and 24 h. However, there was no significant reduction in total serum bilirubin values during the study period. In the albumin‐treated group, the mean serum unbound bilirubin reduction from the baseline level at the end of albumin treatment and at 6 and 24 h was 0.40~0.19, 0.41~0.20 and 0.43~0.20 μg/dL, respectively.Conclusions: The results suggest that albumin priming may be effective for an immediate reduction in serum unbound bilirubin values, the fraction that is potentially neurotoxic.