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Possible effects of antioxidant status on increased platelet aggregation in childhood iron‐deficiency anemia
Author(s) -
Tekin Demet,
Yavuzer Sema,
Tekin Mustafa,
Akar Nejat,
Cin Şükrü
Publication year - 2001
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2001.01329.x
Subject(s) - medicine , antioxidant , superoxide dismutase , glutathione peroxidase , platelet , catalase , oxidative stress , glutathione , platelet aggregation , anemia , endocrinology , immunology , biochemistry , enzyme , biology
Background: Alterations in platelet function and antioxidant status in children with iron‐deficiency anemia (IDA) have been reported previously. The present study was performed to better understand possible interactions between these two systems.Methods: Erythrocyte superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH‐Px) activity and platelet function were evaluated in 15 children (aged 11/2–15 years) with IDA. The antioxidant enzyme activity was determined spectrophotometrically. Platelet aggregation and secretion studies were performed using impedance and bioluminescence methods, respectively. Ten age‐matched healthy children were included as a control group.Results: There were no differences in SOD and CAT activities between patients and controls. However, GSH‐Px activity was significantly lower in the iron‐deficient children. Platelet aggregation responses to collagen and ADP were also significantly higher in iron‐deficient children than in controls.Conclusions: Decreased antioxidant defense in IDA may cause increased oxidant stress, which, in turn, may result in a tendency towards platelet aggregation.