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Usefulness of serum fibrinogen degradation product‐E in sporadic cases of classical hemolytic uremic syndrome
Author(s) -
Aihara Yukoh,
Nakamura Tomoko,
Unayama Takao,
Yoshida Yoshiyuki,
Yokota Shumpei
Publication year - 2000
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2000.01266.x
Subject(s) - medicine , fibrinogen , disease , gastroenterology , shiga toxin , immunology , escherichia coli , biochemistry , chemistry , gene
Background : Hemolytic uremic syndrome (HUS) associated with Shiga toxin (Stx)‐producing Escherichia coli O157:H7 infection is one of the diseases causing acute renal failure in young children. Although HUS is still a serious disease in children, no reliable predictive markers for HUS nor markers of disease severity are available so far. Recently, we experienced a sporadic case of typical HUS caused by Stx‐producing E. coli O157:H7 and detected, at the prodromal stage, a high level of serum fibrin/fibrinogen degradation product‐E (FDP‐E) fraction.Methods: To assess the usefulness of FDP‐E for the treatment of HUS in clinical practice, we retrospectively examined serum levels of FDP‐E in 22 patients with bloody diarrhea with or without HUS.Results: There were significantly increased levels of serum FDP‐E in patients with HUS, but not in those without HUS. Furthermore, serum levels of FDP‐E may correlate with disease severity in patients with HUS.Conclusions: These results suggest that serum levels of FDP‐E may be a useful marker of HUS in clinical practice.