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Anti‐interleukin‐8 auto‐antibodies in cerebrospinal fluid of children with purulent meningitis
Author(s) -
Takasaki Jiro,
Ogawa Yunosuke
Publication year - 2000
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2000.01198.x
Subject(s) - medicine , cerebrospinal fluid , meningitis , antibody , immunology , pathology , pediatrics
Background: Cerebrospinal fluid (CSF) of patients with purulent meningitis contains a high concentration of interleukin (IL)‐8. Recently, the presence of anti‐IL‐8 auto‐antibodies was noted in blood and alveolar fluid. Therefore, measurement of the concentration of anti‐IL‐8 auto‐antibodies was attempted in CSF of children with and without meningitis.Methods and Results: We measured the concentration of anti‐IL‐8 auto‐antibodies in CSF of children with purulent or aseptic meningitis and those without meningitis. The CSF obtained on admission showed a significantly higher concentration of anti‐IL‐8 IgG and IgM auto‐antibodies in children with purulent meningitis, compared with those with aseptic meningitis or without meningitis. Among the three groups of children, the concentration of IL‐8 was also significantly higher in CSF of children with purulent meningitis.Conclusion: Because the anti‐IL‐8 IgG auto‐antibody binds to IL‐8 and inhibits IL‐8 interaction with specific receptors on neutrophils, the presence of anti‐IL‐8 auto‐antibodies seems to provide a mechanism that limits the bioavailability of free IL‐8 in CSF.