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Serum hepatocyte growth factor levels in Henoch–Schönlein purpura
Author(s) -
Nishida MASASHI,
Kawakatsu HIDEKAZU,
Ishiwari KOHHEI,
Tamai MEGUMI,
Sawada TADASHI,
Nishimura MASATO,
Yoshimura MANABU
Publication year - 1999
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.1999.01112.x
Subject(s) - medicine , hepatocyte growth factor , henoch schonlein purpura , purpura (gastropod) , vasculitis , immune system , immunology , gastroenterology , systemic vasculitis , receptor , ecology , disease , biology
Background : Henoch–Schönlein purpura (HSP) is the most common form of vasculitis in children. The potential role of hepatocyte growth factor (HGF) in acute immune‐mediated vasculitis has not been elucidated. Methods : Serum HGF levels were determined in patients with HSP. Results : In patients with acute‐phase HSP, mean (~SD) serum HGF levels were 0.32~0.14 ng/mL and were significantly higher than those in the control group (0.11~0.10 ng/mL). This elevation of serum HGF levels recovered to control levels in parallel with improvement of the clinical symptoms. Conclusions : It is suggested that elevation of serum HGF levels in patients with acute‐phase HSP may reflect endothelial cell damage or dysfunction in HSP.