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Bronchial responsiveness to beta‐adrenergic stimulation and enhanced beta‐blockade in asthma
Author(s) -
Boskabady Mohammad Hossen,
Snashall Phyllip Duglas
Publication year - 2000
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1046/j.1440-1843.2000.00236.x
Subject(s) - medicine , propranolol , asthma , isoprenaline , asymptomatic , inhalation , bronchodilator , beta (programming language) , adrenergic , stimulation , anesthesia , receptor , computer science , programming language
Objective : Beta‐adrenergic blocking drugs have no effect on the airways of normal subjects but in asthma even small doses may cause severe deterioration. A seemingly obvious explanation for this abnormal sensitivity is that asthmatic airways, but not normal airways, are tonically dilated by the sympatho‐adrenal system. However, studies suggest that sympatho‐adrenal activity is normal in asthma, as is bronchial sensitivity to β‐agonists. The present study re‐examines bronchial β‐adrenergic sensitivity in asthma and also measures antagonism produced in normal and asthmatic bronchi by a beta‐blocking drug. Methodology : The threshold bronchodilator doses of inhaled isoprenaline (dose required for a 35% increase in specific airway conductance ‘PD 35 ’) was measured in 11 normal and 14 asthmatic adults on two separate occasions. After administering propranolol (inhaled or intravenously) PD 35 was remeasured. Results : Sensitivity to isoprenaline was greater in symptomatic asthmatics (PD 35 = 0.003 μmol) than in asymptomatic asthmatics (PD 35 = 0.021 μmol) and in non‐asthmatics (PD 35 = 0.123 μmol; P < 0.001 in each case). Symptomatic asthmatics also showed 66‐fold more antagonism than non‐asthmatics when they were given propranolol by inhalation ( P < 0.001) and sixfold more with intravenous propranolol ( P = 0.005). Conclusions : The increased sensitivity of asthmatics to inhaled isoprenaline suggests that they may also be more sensitive to their endogenous adrenaline, which may thus dilate and stabilize their airways. Taken with enhanced antagonism by propranolol, this provides insight into the aggravation of asthma by beta‐blocking drugs.