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Reversible airway obstruction in rheumatic mitral valve disease
Author(s) -
NOUR Mahmoud,
MUSTAFA Khatim,
MOUSA Khadadah,
ABUL Adnan,
SHUHAIBAR Hani,
Mohsen Abdul Mohsen
Publication year - 1998
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1046/j.1440-1843.1998.d01-4.x
Subject(s) - medicine , salbutamol , anesthesia , inhalation , airway resistance , airway obstruction , placebo , plethysmograph , cardiology , obstructive lung disease , airway , copd , asthma , alternative medicine , pathology
Lung function was studied in 24 patients with advanced mitral stenosis scheduled for mitral valve replacement (MVR), and revealed an obstructive ventilatory pattern [rewording of this sentence OK] . Forty per cent of the patients had a forced expiratory volume in 1 s (FEV 1 )<60% of that predicted in the preoperative period. Twenty‐five per cent of those operated upon showed a similar pattern up to 110 weeks postoperatively. A blind study of the effect of placebo and β 2 agonist (salbutamol) inhalation was performed preoperatively and 6 months postoperatively, to evaluate the reversibility of airflow obstruction in these patients, flow volume curve and body plethysmographic measurement of airway resistance (Rex) and intrathoracic gas volume (VTG). Patients in the pre and postoperative period showed a significant difference between the placebo and the β 2 agonist responses for FEV 1 , FEV 1 as percentage of FVC (FEV 1 % FVC), peak expiratory flow rate (PEFR), flow rate of 50% of expiratory vital capacity ([¨max 50 ), Rex and VTG ( P <0.001). We conclude that salbutamol inhalation improves obstructive impairment in patients with MVR pre‐ and postoperatively.