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Sarcoidosis induced by interferon therapy for chronic myelogenous leukaemia
Author(s) -
KIKAWADA Masayuki,
ICHINOSE Yuichi,
KUNISAWA Akira,
YANAGISAWA Naoshi,
MINEMURA Kazushige,
KASUGA Ikuma,
YONEMARU Makoto,
KAWANISHI Keiichi,
TAKASAKI Masaru,
TOYAMA Keisuke
Publication year - 1998
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1046/j.1440-1843.1998.d01-1.x
Subject(s) - medicine , sarcoidosis , granuloma , biopsy , lymph node , interferon , lymph , subcutaneous injection , pathology , dermatology , immunology
A 31‐year‐old male was diagnosed as having chronic myelogenous leukaemia and has been treated with hydroxyurea and interferon‐α since February 1995. After 16 months, he complained of low‐grade fever and a cough. Bilateral hilar lymph node enlargement was detected on the chest X‐ray film and multiple subcutaneous erythematous nodules appeared. A skin biopsy revealed subcutaneous sarcoid granuloma. Two months after the cessation of interferon therapy, the subcutaneous nodules and the hilar lymph node enlargement resolved. It is possible that continuous interferon administration can promote granuloma formation in sarcoidosis by activating T cells and macrophages.