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Role of PTEN and MMP‐7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma
Author(s) -
Zheng HuaChuan,
Sun JinMin,
Li XiaoHan,
Yang XueFei,
Zhang YinChang,
Xin Yan
Publication year - 2003
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2003.01542.x
Subject(s) - pten , matrix metalloproteinase , angiogenesis , gastric carcinoma , metastasis , cancer research , pathology , cancer , medicine , biology , microbiology and biotechnology , signal transduction , pi3k/akt/mtor pathway
To investigate the role of PTEN and matrix metalloproteinase‐7 (MMP‐7) expression in tumorigenesis and progression of gastric carcinoma, their expression in 113 gastric carcinomas was studied by immunohistochemistry. Microvessel density (MVD) was counted using the anti‐CD34 antibody. The expressions of PTEN and MMP‐7, and MVD were compared with the clinicopathological parameters of tumors, and the relationship between PTEN and MMP‐7 expression and MVD was analyzed. It was found that PTEN was expressed less frequently in primary gastric carcinoma cells than in adjacent epithelial cells ( P < 0.05), whereas this was reversed for MMP‐7 ( P < 0.05). PTEN expression was negatively correlated with invasion, metastasis, growth pattern, Lauren's classification and histological classification ( P < 0.05). Matrix metalloproteinase‐7 expression was positively associated with tumor size, Borrmann's classification, invasive depth, metastasis and TNM staging ( P < 0.05), but negative with PTEN expression ( P < 0.05). A positive correlation of MVD with tumor size, invasive depth, metastasis and TNM staging was found ( P < 0.05). Microvessel density depended on decreased PTEN expression and increased MMP‐7 expression ( P < 0.05). The results of the present study suggested that down‐regulated PTEN expression and up‐regulated MMP‐7 expression were greatly implicated in tumorigenesis and progression of gastric carcinoma. Close correlation between PTEN on MMP‐7 expression provided a novel insight into the regulatory effects of PTEN on MMP‐7 expression in gastric carcinoma.