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Myxoid endometrial stromal sarcoma of the uterus
Author(s) -
Kasashima Satomi,
Kobayashi Masako,
Yamada Mitsuoki,
Oda Yoshio
Publication year - 2003
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2003.01525.x
Subject(s) - endometrial stromal sarcoma , pathology , stromal cell , smooth muscle tumor , sarcoma , myometrium , stromal tumor , uterus , desmin , metastasis , medicine , biology , immunohistochemistry , cancer , vimentin
A rare case of a myxoid type of endometrial stromal sarcoma of the uterus in a 41‐year‐old woman is reported. A tumor was found in the myometrium and was well circumscribed, measuring 9 × 7 × 7 cm in size. The tumor was mainly composed of a hypocellular area with tumor cells separated by prominent myxoid stroma. The tumor cells were spindle‐shaped and resembled endometrial stromal cells. Numerous small thin‐walled vessels were seen throughout the tumor. Immunohistochemically, the tumor cells were diffusely stained for estrogen and progesterone receptors and CD10, and focally and weakly for HHF35, α‐smooth muscle actin and desmin, but not stained for h‐caldesmon. These results indicated that the tumor originated from endometrial stromal cells. The tumor had an increased mitotic activity (MIB‐1 labeling index: 1–10%), and focally showed nuclear pleomorphism. Thus, this tumor had a malignant potential and was diagnosed as a myxoid type of low‐grade endometrial stromal sarcoma. The patient is currently well with no evidence of local recurrence or metastasis 21 months after the operation. This case indicates a wide morphological spectrum of endometrial stromal tumor. A myxoid endometrial stromal sarcoma should be considered in the different diagnosis of the intramural myxoid tumors in the uterus.