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Genetic analysis of cutaneous squamous cell carcinomas arising from different areas
Author(s) -
Hayashi Masahiro,
Tamura Gen,
Kato Noriko,
Ansai Shinichi,
Kondo Shigeo,
Motoyama Teiichi
Publication year - 2003
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2003.01523.x
Subject(s) - carcinogenesis , loss of heterozygosity , pathology , skin cancer , scars , sun exposure , biology , dermatology , cancer , allele , medicine , gene , genetics
Although cutaneous squamous cell carcinomas (SCC) occur most frequently in sun‐exposed areas of the skin, they can also arise in non‐sun‐exposed areas. Some risk factors for cutaneous SCC, such as ultraviolet (UV) light, are well known. However, the major factor for carcinogenesis may depend on the site of the tumor as well as the ethnicity of the patient. In this study we examined 41 Japanese cutaneous SCC cases, focusing on the area of appearance and the presence of genetic alteration, with 27 cases from sun‐exposed areas, 10 from non‐sun‐exposed areas (excluding genital areas), and four from burn scars from sun‐exposed areas. Squamous cell carcinomas arising in sun‐exposed areas showed less frequent p53 gene mutations compared to SCC arising in non‐sun‐exposed areas. Ultraviolet light‐specific mutations were found in only two cases of SCC from sun‐exposed areas. Human papilloma virus (HPV) DNA was detected in two cases (7.4%) of the sun‐exposed areas and none of the non‐sun‐exposed or scar areas. The frequency of loss of heterozygosity on D5S178 in non‐sun‐exposed SCC was significantly higher than in sun‐exposed SCC. Furthermore, the incidence of fractional allelic loss (FAL) was significantly higher in non‐sun‐exposed SCC than in sun‐exposed SCC. Our findings suggest that sun‐exposed SCC in Japan may be relatively less involved with p53 mutation, and that non‐sun‐exposed SCC acquire more genetic alterations than sun‐exposed SCC.