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Adenoma, adenocarcinoma and mixed carcinoid‐adenocarcinoma arising in a small lesion of the colon
Author(s) -
Jiao YuFei,
Nakamura Shinichi,
Arai Tomio,
Sugai Tamotsu,
Uesugi Noriuki,
Habano Wataru,
Suzuki Masamichi,
Tazawa Hideki,
Goukon Yuji
Publication year - 2003
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2003.01500.x
Subject(s) - adenocarcinoma , pathology , histogenesis , carcinoembryonic antigen , carcinoid tumors , adenoma , submucosa , tubular adenoma , medicine , biology , immunohistochemistry , colorectal cancer , cancer , colonoscopy
A unique tumor measuring 8 × 8 × 5 mm and composed of adenoma, adenocarcinoma and mixed carcinoid‐adenocarcinoma arising in the ascending colon is reported. The mixed carcinoid‐adenocarcinoma, in which adenocarcinomatous and carcinoid components intermingled, originated in the mucosa, penetrated the muscularis mucosa and extended into the submucosa. Immunohistochemically, carcinoid cells were positive for neuroendocrine markers and adenocarcinoma cells were intracytoplasmicly positive for carcinoembryonic antigen. Ultrastructurally, membrane‐bound electron dense granules varying in shape, size and electron density were detected in the cytoplasm of carcinoid cells. No mutations of p53 and k‐ras genes were detected in adenomatous, adenocarcinomatous or mixed carcinoid‐adenocarcinoma components. The morphological appearances of the present case strongly suggests the histogenesis of this tumor in an adenoma‐adenocarcinoma‐carcinoid tumor sequence.