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Y‐box binding protein expression in thyroid neoplasms: Its linkage with anaplastic transformation
Author(s) -
Ito Yasuhiro,
Yoshida Hiroshi,
Shibahara Kotaro,
Uruno Takashi,
Nakano Keiichi,
Takamura Yuuki,
Miya Akihiro,
Kobayashi Kaoru,
Yokozawa Tamotsu,
Matsuzuka Fumio,
Uchimi Takeshi,
Kuwano Michihiko,
Miyoshi Eiji,
Matsuura Nariaki,
Kuma Kanji,
Miyauchi Akira
Publication year - 2003
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2003.01494.x
Subject(s) - anaplastic carcinoma , thyroid , pathology , immunohistochemistry , thyroid carcinoma , cancer research , transcription (linguistics) , neoplastic transformation , malignant transformation , biology , messenger rna , gene , carcinoma , medicine , carcinogenesis , endocrinology , genetics , linguistics , philosophy
Recent studies have demonstrated that Y‐box binding protein (YB‐1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB‐1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB‐1, and only moderate overexpression of YB‐1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB‐1. YB‐1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB‐1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.