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Splenic lymphangioma with papillary endothelial proliferation: A case report and review of the literature
Author(s) -
Takayama Akiko,
Nakashima Osamu,
Kobayashi Keita,
Kojiro Masamichi
Publication year - 2003
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2003.01493.x
Subject(s) - pathology , lymphangioma , cd31 , cd34 , lymph , medicine , papillary tumor , lymphatic system , fibrosis , lumen (anatomy) , immunohistochemistry , anatomy , biology , stem cell , genetics
A 76‐year‐old man complained of difficulty breathing. A solitary mass was found in the spleen by ultrasonography and the tumor was excised. Grossly, the tumor was 3.9 × 2.9 cm in size, solid and brownish in color. A stellate scar‐like fibrosis was observed in the center of the tumor. Histologically, the tumor consisted of the proliferation of irregular and small lymph vessel‐like spaces, with sclerotic change in the center. The lymph vessel‐like spaces showed papillary projections of the lining cells. The lumen contained amorphous proteinaceous fluid. Immunohistochemically, the lining cells of lymph vessel‐like spaces were positive for endothelial markers (CD31, CD34, factor VIII‐related antigen), and bound Ulex europaeus agglutinin‐1. The tumor was diagnosed as splenic lymphangioma, but its appearance was rather unusual for a typical splenic lymphangioma because of the presence of papillary endothelial proliferation and scar‐like fibrosis. Splenic lymphangioma with papillary endothelial proliferation is uncommon, and there have been only four cases reported.