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Localization of antigen‐presenting cells in Helicobacter pylori ‐infected gastric mucosa
Author(s) -
Suzuki Tatsuhiko,
Kato Katsuaki,
Ohara Shuichi,
Noguchi Kenji,
Sekine Hitoshi,
Nagura Hiroshi,
Shimosegawa Tooru
Publication year - 2002
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2002.01347.x
Subject(s) - immune system , gastric mucosa , cd80 , lamina propria , antigen , cytotoxic t cell , immunology , helicobacter pylori , biology , antigen presentation , antigen presenting cell , t cell , cd40 , stomach , epithelium , in vitro , biochemistry , genetics
Helicobacter pylori (HP) infection is known to induce the specific immune response in the gastric mucosa. The immune response is triggered by presentation of antigen peptides on the major histocompatibility assembly of the antigen‐presenting cells (APC) with the assistance of costimulatory molecules such as B7‐1 (CD80) and B7‐2 (CD86). Their counter‐receptors or ligands on T cells are CD28 or cytotoxic lymphocyte‐associated molecule‐4. The aim of the present study was to clarify the localization of APC and their relation with T cells in HP‐infected human gastric mucosa. Our findings suggest that the macrophages in the lamina propria may mainly act as APC in the HP‐infected gastric mucosa, and the triggered immune response might be involved in the mucosal immune response in the inflamed gastric mucosa to invasive antigens related to HP organisms.