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Esophageal basaloid carcinoma with marked myoepithelial differentiation
Author(s) -
Hishida Tomoyuki,
Nakanishi Yukihiro,
Shimoda Tadakazu,
Igaki Hiroyasu,
Tachimori Yuji,
Kato Hoichi,
Yamaguchi Hajime,
Iinuma Gen
Publication year - 2002
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2002.01346.x
Subject(s) - myoepithelial cell , pathology , carcinoma , adenoid cystic carcinoma , cytokeratin , epithelium , stroma , esophagus , anatomy , cribriform , histogenesis , biology , immunohistochemistry , medicine
A case of esophageal basaloid carcinoma with marked myoepithelial differentiation in a 60‐year‐old man is reported. The tumor arose as an exophytic mass, measuring 65 × 60 mm, in the middle thoracic esophagus. Approximately two‐thirds of the tumor surface was covered with non‐cancerous esophageal epithelium. The depth of tumor invasion was limited to the submucosal layer. Histologically, about 70% of the tumor contained a typical basaloid carcinoma component and about 30% contained glandular and intercalated duct‐like components with distinct epithelial and myoepithelial differentiation. The tumor presented no component of distinct squamous cell carcinoma, but a small portion of cribriform‐like structure, which is typical of adenoid cystic carcinoma, was visible. The inner epithelium composing the intercalated duct‐like structure showed immunohistochemical positivity for cytokeratin 14, and the outer epithelium lining adjacent to the stroma showed positivity for α‐smooth muscle actin. These findings supported epithelial/myoepithelial differentiation. To our knowledge, our case is the first patient with an esophageal basaloid carcinoma showing marked myoepithelial differentiation.