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Perivascular myoma: Case report with immunohistochemical and ultrastructural studies
Author(s) -
Mikami Yoshiki,
Shiomi Tatsushi,
Manabe Toshiaki
Publication year - 2002
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2002.01318.x
Subject(s) - desmin , pathology , anaplasia , immunohistochemistry , ultrastructure , biology , anatomy , hemangiopericytoma , cytoplasm , vimentin , medicine , microbiology and biotechnology
A subcutaneous myopericytoma‐type perivascular myoma arising in the elbow of a 61‐year‐old woman is described. The tumor was well demarcated and consisted microscopically of small ovoid and spindle cells arranged in a concentric fashion, surrounding small to medium‐sized vessels and imparting a superficial resemblance to hemangiopericytoma. In some areas, the cellular whorls were separated by myxoid stroma. Cells located between cellular whorls appeared immature with scant cytoplasm but did not show distinct nuclear anaplasia, increased mitoses or foci of necrosis. Immunohistochemistry showed that constituent cells were positive for α ‐smooth muscle actin and desmin. Electron microscopy disclosed that the immature‐looking cells, as well as the ovoid and spindle‐shaped cells, possessed focal densities along with thin filaments, subplasmalemmal densities, pinocytotic vesicles and an external lamina. These ultrastructural and immunohistochemical features indicate a myoid nature of pericytic cells and justify this type of neoplasm being categorized as perivascular myoid tumor.